Oral Presentation 10th Australian Peptide Conference 2013

Epitope binning assays on monoclonal antibodies using label-free biosensor (#11)

Yasmina Abdiche 1
  1. Rinat Laboratories, Pfizer Inc, South San Francisco, CA, United States

In the discovery of therapeutic antibodies, finding an appropriate antibody/epitope pair is challenging because both the epitope and the antibody can have undesirable properties that frustrate the intended therapeutic application. Since an antibody’s epitope and functional activity are correlated, it is helpful to organize a panel of antibodies into epitope families or “bins”. This talk will describe how epitope binning assays can be performed on label-free biosensors.