Poster Presentation 10th Australian Peptide Conference 2013

Drug delivery systems have continuously evolved to improve the efficiency of the cancer treatment. In this field, silica nanoparticles (SiNPs) are a class of promising nanomaterials.¹  Their easy synthesis by sol-gel condensation, tuneable size control, high surface areas, chemical stability, fonctionalizable surfaces and biocompatibility³  make SiNPs adequate tools for theranostic applications. In this context, we develop an efficiency strategy to obtain in a single step, multifunctional silica nanoparticles. It relies on the use of trialkoxysilyl-peptide hybrid building blocks developed in our laboratory⁴² . Noteworthy, the use of the hybrid peptides do not require any prior functionalization of the silica surface, nor chemoselective reaction, and proceeds at RT in water.

Noteworthy, the derivatisation of fluorescein with trialkoxisilane moiety, enables the direct synthesis of fluorescent NPs, avoiding any unwanted bleaching.

 The synthesis of hybrid alkoxysilane bioactive peptides and enzyme-sensitive sequences for a releasing system based on shell degradation is reported. At last, the simple grafting of SiNPs using sol-gel process will be presented.